Graham Hone
Princeton University
Total Synthesis, Methodology Development
Graham Hone has been part of the Center since the inception of Phase II. As a member of the Sorensen group he was part of a team seeking to really challenge C-H functionalization techniques in complex molecular scaffolds.
Working in a collaborative team that included members from the Davies and Yu groups Graham developed a concise synthesis of the core scaffold of the indoxamycin class of natural products exploiting sequential C-H functionalization strategies.
In 2016 Graham graduated and took a position at Macroceutics Pharmaceuticals, NJ.
Center Activities:
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10/2018
Rhodium-Catalyzed C–H Amination: A Case Study of Selectivity in C–H Functionalization Reactions
RESEARCH
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05/2016
Rapid Construction of a Benzo-Fused Indoxamycin Core Enabled by Site-Selective C−H Functionalizations
RESEARCH
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06/2015
An expedient synthesis of maraviroc (UK-427,857) via C–H functionalization
RESEARCH
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01/2015
The Birkman Method
EDUCATION
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04/2014
2014 USA Science and Engineering Festival
OUTREACH