Transition metal-catalyzed C–H activation reactions: diastereoselectivity and enantioselectivity

Ramesh Giri, Bing-Feng Shi, Keary M. Engle, Nathan Maugel and Jin-Quan Yu

Chem. Soc. Rev.,
2009, 3242-3272; 10.1039/B816707A


This review from the Yu group focuses on the selectivity possible through transition metal-catalyzed C–H functionalization. Collecting together reactions effective and relevant to the realm of organic synthesis the subjects of diastereo- and enantioselectivity are used as measures to judge the efficacy of these reactions.

Selectivity is key to the development of effective C–H functionalization. The more that the factors that impact this are explored the more informed the design of next generation catalysts and transformation will be.

This perspective allows the reader to gain a real understanding of the challenges facing the researcher when trying to accomplish selective C–H functionalization and summarizes some of the cutting-edge research being done in this field. It also highlights some of the future challenges faced by C–H functionalization before it becomes a mainstream logic of organic synthesis.

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