Functionalization of Carbon–Hydrogen Bonds Through Transition Metal Carbenoid Insertion

Huw M. L. Davies, Allison R. Dick

Topics in Current Chemistry,
2009, 303-345; 10.1039/B816707A


The Davies group have put together this book chapter that highlights recent developments in the field of C–C bond formation through functionalization of C–H bonds. It provides a historical context to these highlights, summarizing intra-molecular carbenoid C–H insertion and develops the story to the extension to the inter-molecular version.

This perspective provides a narrative which concludes with the application and synthetic utility of the carbenoid C–H insertion reaction in the total synthesis of a number of natural products and pharmaceuticals.

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