Factors Controlling Stability and Reactivity of Dimeric Pd(II) Complexes in C–H Functionalization Catalysis

Brandon E. Haines, John F. Berry, Jin-Quan Yu, and Djamaladdin G. Musaev

ACS Catalysis,
2016, 6, (2), 829-839; 10.1021/acscatal.5b02447


Pd-catalyzed C–H activation has become established as one of the most reliable and versatile methods to selectively functionalize both sp2 and sp3 C–H bonds. A particular emphasis within the CCHF has been the work driven by the Yu group on the use of dimeric catalyst systems in directing group assisted C–H Functionalization.

This collaborative study brings together the Yu, Berry and Musaev groups to investigate the factors that control the stability and reactivity of these dimeric systems. Through a combination of experimental and theoretical techniques it was outlined how the nature of the bridging ligands can be used to fine tune the electronic nature of the metal centers in the catalyst.

These finding will inform the design of future palladium catalyst and ligand environments.

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