Understanding the Reactivity of Pd(0)/PR3-Catalyzed Intermolecular C(sp3)-H Bond Arylation

Travis M. Figg, Masayuki Wasa, Jin-Quan Yu and Djamaladdin G Musaev

J. Am. Chem. Soc.,
2013, 135, (38), 14206-14214; 10.1021/ja4053416


Among the various types of redox-catalysis employed in Pd-Catalyzed C–H Functionalization the Pd(0)/Pd(II) manifold by the oxidative addition of aryl halides is priveledged; no external oxidant is required. While intra-molecular variant arylations of C(sp3)-H bonds have been demonstrated, but an intermolecular version had not been described until a recent report from the Yu Group. This collaborative report from the Yu and Musaev group interogates the factors involved in this transformation and highlights the importance of the conditions employed.

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