Palladium-Catalyzed aerobic oxidation reactions have been of industrial significance and extensive research efforts for nearly 60 years. A significant inflection point came around 20 years ago with the introduction of systems incorporating ancillary ligands.
This review from the Stahl group focuses on the crucial role that these ligands play in the reactions. The use of these ligands has contributed to significant expansion in the scope of accessible aerobic oxidation reactions. This review surveys the different ligands that have been used in this chemistry, and where possible discusses the mechanistic insights into the role the ligand plays.