Led by Jamal Musaev
One of the central thrusts of this multi-faceted research project is to build up the mechanistic understanding of C-H functionalization in an aim to develop:
- Next-generation, selective, and more efficient catalysts including earth-abundant transition metals.
- Predictive models for determining site selectivity in complex target synthesis.
Predictive models for C–H modification are challenged and refined in the context of the late-stage C-H functionalization, novel disconnections in complex target synthesis, and design of new approaches for novel materials preparation and drug discovery. Thus, fundamental (computational and mechanistic) studies are the cornerstone of the proposed multi-faceted research project and designed to guide and impact selective C-H functionalization strategies through new and more efficient catalyst design and direct elucidation of both the successes and limiting factors of current C-H functionalization methodologies in preparation of novel materials, natural products, fine chemistry and effective drugs.
In order to gain a comprehensive mechanistic understanding of the factors that control chemo-, regio-, and stereoselectivity in C–H functionalization, during the reporting period, investigators have launched several cutting-edge collaborative (experimental and theoretical) projects. These multi-disciplinary research efforts offer the most compelling and most needed fundament knowledge for the design of new and more efficient catalysts for the C-H bond functionalization to improve the application of this revolutionary synthetic strategy for materials preparation, as well as natural product, fine chemistry and effective drug synthesis.