CCHF Research | Applications in the Pharmaceutical Sciences
Led by Huw Davies
The main CCHF wide applications of C–H functionalization to pharmaceutically relevant targets is achieved through collaborative studies with Novartis, in which they have sponsored two post docs and two graduate students to work on these challenges.
Related Publications:
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04/2017
Copper-Mediated Late-Stage Functionalization of Heterocycle-Containing Molecules
RESEARCH
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01/2017
Understanding Flavin-Dependent Halogenase Reactivity via Substrate Activity Profiling
RESEARCH
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08/2016
Potassium tert-Butoxide-Catalyzed Dehydrogenative Cross-Coupling of Heteroarenes with Hydrosilanes
RESEARCH
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02/2016
Pd-Catalyzed α-Selective C–H Functionalization of Olefins: En Route to 4-Imino-β-Lactams
RESEARCH
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10/2015
Catalytic C–H bond silylation of aromatic heterocycles
RESEARCH
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09/2015
The medicinal chemist's toolbox for late stage functionalization of drug-like molecules
RESEARCH
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07/2015
Chemotherapeutic natural product ET-743
RESEARCH
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07/2015
Pyridine N-Oxide vs Pyridine Substrates for Rh(III)-Catalyzed Oxidative C–H Bond Functionalization
RESEARCH
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06/2015
An expedient synthesis of maraviroc (UK-427,857) via C–H functionalization
RESEARCH
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01/2015
Silylation of C–H bonds in aromatic heterocycles by an Earth-abundant metal catalyst
RESEARCH
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01/2015
Late-stage C–H functionalization of complex alkaloids and drug molecules via intermolecular rhodium-carbenoid insertion
RESEARCH
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10/2013
Profound Methyl Effects in Drug Discovery and a Call for New C–H Methylation Reactions
RESEARCH
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06/2013
C-H Functionalization Logic Enables a Synthesis of (+)-Hongoquercin A and Related Compounds
RESEARCH
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04/2011
Divergent C–H Functionalizations Directed by Sulfonamide Pharmacophores: Late-Stage Diversification as a Tool for Drug Discovery
RESEARCH