04/2013

This collaborative project between the Yu and Baran Groups, both at the Scripps Research Institute highlights the impact that the novel disconnection strategies being developed within the CCHF can have upon strategies for complex molecule synthesis.

This project also highlights the potential for Center members to form collaborative projects with non-Center members to facilitate the application of methods developed within the Center to the wider community. Effective and selective C–H oxidation and methylation unveil a streamlined synthesis of a library of structurally distinct analogues, with diversification being acheived at a late stage of the synthesis.

The alternative method for constructing this library of analogues would have required incorporation of the substitutents for each analogue at a much earlier stage, significantly increasing the work and steps required for their construction.