09/2016

The Yu and Dai groups have established a program translating the knowledge and findings regarding palladium-catalyzed C–H activation to copper-based systems.

In this latest report they describe how a combination of monodentate, weakly coordinating directing group with an external oxazoline ligand promotes ortho C–H hydroxylation and amination.

This is the first disclosure of this approach in a copper-based system and significantly expands the scope and potential of these C–H functionalization reactions based on earth-abundant element catalysis.