Palladium(II)-Catalyzed C–H Activation/C–C Cross-Coupling Reactions: Versatility and Practicality

Xiao Chen, Keary M. Engle, Dong-Hui Wang, and Jin-Quan Yu
Angew. Chem. Int. Ed.,
2009, 5094-5115; 10.1002/anie.200806273


This review by the Yu group provides an excellent introduction to the field of Pd-catalyzed C–H Activation/C–C bond forming reactions. It highlights the four main modes of Pd-catalyzed formation of C–C bonds from C–H bonds.

A detailed discussion is then presented on the Pd(II)/Pd(0)-catalyzed reaction of C–H bonds, providing a perspective on the potential of this emerging methodology and impact it could have on the rapid construction of a broad range of molecules.

This review highlights many of the powerful transformation that C–H Functionalization can offer. Furthermore a detailed discussion of the future directions and developments required in this field for it to reach its full potential is explored.

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