Sequential Transformations to Access Polycyclic Chemotypes: Asymmetric Crotylation and Metal Carbenoid Reactions

Wu, J., Becerril, J., Lian, Y., Davies, H. M. L., Porco, J. A.; Panek, J. S.

Angew. Chem. Int. Ed.,
2011, 5938-5942; 10.1002/anie.201101366


C-H Functionalization not only offers the opportunity to perform more established synthetic disconnections in a more straightforward and sustainable fashion, furthermore it can provide new and powerful disconnections providing access to otherwise unobtainable organic motifs.

This collaborative study between the Davies group and the Center for Chemical Methodology and Library Development (CMLD) exploits some of these new tranformations to form the basis for a library of diverse compounds mapping previously inaccessible sections of chemical space.

This compound library will go on to be used in assays against a host of different biological targets. It has been documented that there is a bias in pharmaceutical targets towards compounds that can be easily made using current technologies. The CCHF aims to open up greater spans of chemical space by developing and establishing new transformations to access valuable molecular motifs.

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