Copper-Catalyzed Bromination of C(sp3)−H Bonds Distal to Functional Groups

Tao Liu, Michael C. Myers, Jin-Quan Yu

Angew. Chem. Int. Ed.,
2017, 129, 1, 312-315; DOI: 10.1002/ange.201608210


Selective bromination of γ-methylene C(sp3)−H bonds of aliphatic amides and δ-methylene C(sp3)−H bonds of nosyl-protected alkyl amines are developed using NBS as the brominating reagent and catalytic amount of CuII/phenanthroline complexes as the catalyst. Aryl and benzylic C−H bonds at other locations remain intact during this directed radical abstraction reaction.

Related Content

Stay Connected to the CCHF...

  Upcoming Events

Copyright © YEAR Center for Selective C–H Functionalization

This work was supported by NSF under the CCI Center for Selective C–H Functionalization, CHE-1700982. Any opinions, findings, and conclusions or recommendations expressed here are those of the authors and do not necessarily reflect the views of the National Science Foundation (NSF).