Selective Intermolecular Amination of C-H Bonds at Tertiary Carbon Centers

Jennifer L. Roizen, David N. Zalatan and Justin Du Bois

Angew. Chem. Int. Ed.,
2013, 52, 11343-11346; 10.1002/anie.201304238


A method for intermolecular amination of tertiary C–H bonds is described that uses limiting amounts of substrate and a convenient phenol-derived nitrogen source. Structure-selectivity and mechanistic studies suggest that steric interaction between the substrate and active oxidant is the principal determinant of product selectivity.

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