Concise Syntheses of Dictyodendrins A and F by a Sequential C–H Functionalization Strategy

Atsushi D. Yamaguchi, Kathryn M. Chepiga, Junichiro Yamaguchi, Kenichiro Itami and Huw M. L. Davies

J. Am. Chem. Soc.,
2015, 137, 644-647; 10.1021/ja512059d


Through an extensive international collaboration, scientists at the CCHF and the Institute for Transformative Bio-Molecules (ITbM), have synthesized marine alkaloids with anti-cancer and therapuetic properties through a sequential C–H Functionalization strategy.

Employing methods that have been established in the labs of Prof. Huw Davies and Ken Itami graduate students Katie Chepiga and Atsushi Yamaguchi have streamlined the entry into these biologically interesting Natural Products.

The progress of this project was significantly accelerated through engagement in the Science Across Virtual Institutes program, allowing students to travel to international partner labs and gain knowledge and experience. This project crosses borders both scientifically and geographically and shows an extremely strong international collaborative effort.

Related Content