Computationally-Guided Stereocontrol of the Combined C-H Functionalization/Cope Rearrangement
Lian, Y., Davies, H. M. L.
Angew. Chem. Int. Ed.,
2011, 9370-9373; 10.1002/anie.201103568
08/2011
The synthetic utility of the C-H functionalization/Cope rearrangement reaction has been greatly expanded by the design of substrates that will react through a boat transition state instead of a chair transition state. The products are formed with the opposite diastereoselectivity as previously obtained.