Potassium tert-Butoxide-Catalyzed Dehydrogenative Cross-Coupling of Heteroarenes with Hydrosilanes

Submitted by Anton A. Toutov, Wen-Bo Liu, Brian M. Stoltz, and Robert H. Grubbs; Checked by Jose M. Medina and Neil K. Garg

Org. Syn.,
2016, 93, 263-271; DOI: 10.15227/orgsyn.093.0263


The collaboration between the Stoltz and Grubbs groups has developed an effective and general method to convert C–H bonds on typically challenging heterocyclic substrates to versatile C–Si bonds, using Potassium tert-butoxide as the catalyst.

This report in Organic Synthesis provides a detailed account of how to perform this transformation, describing how this can be done reliably on a large scale.