David Sherman
Co-Leader of the Late-Stage C-H Functionalization Theme
University of Michigan at Ann Arbor
Synthetic Chemistry, Marine Microorganisms, Drug Discovery
Center Activities:
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06/2018
Halogenase engineering and its utility in medicinal chemistry
RESEARCH
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03/2018
Structural basis of the Cope rearrangement and cyclization in hapalindole biogenesis
RESEARCH
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11/2017
Synthesis of Diverse 11- and 12-Membered Macrolactones from a Common Linear Substrate Using a Single Biocatalyst
RESEARCH
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08/2017
Function and Structure of MalA/MalA′, Iterative Halogenases for Late-Stage C–H Functionalization of Indole Alkaloids
RESEARCH
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05/2017
Chemoenzymatic Total Synthesis and Structural Diversification of Tylactone-Based Macrolides through Late-Stage Polyketide Assembly, Tailoring, and C–H Functionalization
RESEARCH
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03/2017
Decoding cyclase-dependent assembly of hapalindole and fischerindole alkaloids
RESEARCH
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01/2017
2017 CCHF Annual Meeting
COMMUNITY
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08/2016
OPEN: Engineering Selectivity in Biocatalytic C–H Functionalization
EDUCATION
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06/2016
CCHF Virtual Symposium 04
COMMUNITY
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07/2016
Biochemical and Structural Characterization of MycCI, a Versatile P450 Biocatalyst from the Mycinamicin Biosynthetic Pathway
RESEARCH
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12/2015
Hapalindole/Ambiguine Biogenesis Is Mediated by a Cope Rearrangement, C–C Bond-Forming Cascade
RESEARCH
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07/2015
Evolution of Efficient Modular Polyketide Synthases by Homologous Recombination
RESEARCH
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07/2015
Chemotherapeutic natural product ET-743
RESEARCH
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06/2015
Enzymatic hydroxylation of an unactivated methylene C–H bond guided by molecular dynamics simulations
RESEARCH
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04/2015
2015 MSU Science Festival
OUTREACH
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04/2013
Re-engineering Nature's Catalysts
RESEARCH